Phenoxymethylpenicillin EP Impurity E HCl（Penicilloic acids of phenoxymethylpenicillin） CAS 1049-84-9 (free base)

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.1049-84-9 (free base)
Molecular FormulaC16H20N2O6S
Molecular WeightN/A
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Phenoxymethylpenicillin EP Impurity E HCl（Penicilloic acids of phenoxymethylpenicillin） CAS 1049-84-9 (free base) chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Phenoxymethylpenicillin EP Impurity E HCl（Penicilloic acids of phenoxymethylpenicillin）.

As a process- or degradation-related impurity, Phenoxymethylpenicillin EP Impurity E HCl（Penicilloic acids of phenoxymethylpenicillin） (CAS 1049-84-9 (free base), C16H20N2O6SHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Based on its molecular formula C16H20N2O6SHCl, Phenoxymethylpenicillin EP Impurity E HCl（Penicilloic acids of phenoxymethylpenicillin） contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 404.86 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), Phenoxymethylpenicillin EP Impurity E HCl（Penicilloic acids of phenoxymethylpenicillin） meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC16H20N2O6S HCl
Molecular Weight404.86 g/mol
Purity>95%
StorageStore in a cool place (≤25°C), protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)7.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
Halogen ContentCl-containing
Nitrogen Atoms2
Sulfur Atoms1

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